How Fat Blocks Insulin: Lipotoxicity Explained Simply

Did you know that excess fat—not sugar—is the main reason your body becomes resistant to insulin? In this video, Registered Dietitian Charmaine Dominguez, MPH, RDN breaks down lipotoxicity—the buildup of fat inside your muscle and liver cells that blocks insulin from doing its job.

You’ll learn how certain types of fat (especially intramyocellular fat) interfere with glucose uptake, why insulin resistance happens even in people who “don’t eat much sugar,” and how simple nutrition changes can help your cells become insulin-sensitive again.